Seriously the Brotherhood would be seriously easy to make (as would the Warriors 3 and Enchantress or a Wrecking Crew set)
Blob, Toad, Pyro, Avalanche or take out one or two of the popular members insert Mastermind, Unus the Untouchable, or Destiny, release the two popular members as a TRU exclusive two-pack.
Another plan could be updated Mystique + 3 members, two Toys "R" Us packs. I really just want more X-villains after seeing versions of the Brotherhood being used in the first run of Uncanny X-Force and now in All New X-Men and Uncanny X-Men