Remember, Zach said two villains in this wave have existing figures. Only one is new.
All three heroes have had mates.
Gambit / Uncanny Avengers Rogue and Superior Octopus seem likely.
If the new villain is a Spidey rogue, I guess Boomerang, Prowler, Tombstone, or Jackal.
If the Iron Man villain is new, then I'd guess Ghost, Madame Masque, or Fin Fang Foom.