My only anxiety with this model is that I worry about seeing lesser known teams, especially including villain teams, get represented. Characters that haven't appeared in a movie or live-action series might struggle to be seen as a viable option.
The 4 x 2-pack system worked well for getting a lot of characters out. Wave 60's Strike Force vs Brotherhood set was, IMHO a good way of selling recognisable characters in order to support the release of some villains. And it very nearly completed two teams in a single wave!
Box sets often seem to be team-focused or story-themed, but it's hard to fit two teams into only 5 spots, meaning that the less sellable team might get dumped. I seriously want to see Stryfe and some MLF figures made... but if a big name set like the F4 is not performing as hoped, then I can't see the MLF (or GenX, or the Nasty Boys, or the Upstarts, or the Hellions) having enough pull to warrant their own 5/6-pack.