This is a great question. As someone who happened upon minimates around a decade ago at this point I had no idea there were wave numbers when I first picked up the X-Men Origins: Wolverine wave. And after seeing the inner pamphlet with almost every marvel minimate released to that point (which I personally think was brilliant, and should be brought back maybe including the last few years of mates) I was blown away, and at first found it somewhat overwhelming that there were so many, but quickly transitioned to excitement thinking about the entire 2 inch Marvel universe that could be sitting on my shelf.
It wasn't until I picked up more at TRU that I then happened upon Ivan's Database (which I think would go a long way in being advertised my DST themselves, and compensating Ivan of course). This is when I first learned that there had already been 30-something waves of Marvel minimates on top of numerous box sets, exclusives and TRU exclusive waves. That I would say is when I was both scared for my wallet but also invested in collecting.
So the simple answer is probably yes, but I find it might depend on interest in certain characters and definitely after-market availability, which is supported by Luke and plentiful eBay listings.