If this is Spiderverse based then with what I remember; the main female spiders were Gwen, both versions of Jessica Drew (616 & Ultimate); Spider-girl & Silk.
I personally would hope that the female would be Silk since we only got her once before as a chase figure in the blind packs & not a fan of her secondary prices now. If it isn't her then I'd hope either Spidergirl or the Ultimate Jessica Drew as we have only gotten those characters once before as well. (Not counting the animated Spidergirl since she wears Peter's suit instead of Ben's like the comic version.)
Definitely want an updated comic Miguel. The animated one was nice but we need one with the cape, clawed hands & sculpted arm fins.
If Ben Reilly is involved; my guess is that it would be based off his classic Spiderman suit given that is what he wore during the main story & the Scarlet Spiders side book for Spiderverse but Zach mentioning "Ben Reilly may be invloved" opens up the possibility it is a set based off the Dead No More storyline instead in which case that would make Ben the Jackal.
Really don't want a standard Peter given how many there are available. If it is a comic Spiderverse set; that leaves plenty of choices without Peter of characters that have only been made once, animated only or not at all to pick from for additions to the line.